(Q)SAR and Read Across Analyses in Regulatory Assessment of Pesticide Metabolites and Impurities in the Light of Current Insights and Demands
Authors: Svenja Termeer de Amanqui, Volker Harder
Consumers can be exposed to pesticide residues potentially containing active substances (a.s.) and concomitantly to impurities and residue metabolites. As these substances may have properties of concern for human health, they need to be evaluated. In contrast to the comprehensive toxicological data set of an a.s., toxicological information on metabolites and impurities is generally scarce or non-existent. Based on legislation there is the possibility to apply New Approach Methodologies to assess the toxicological relevance of a.s. metabolites and impurities. (Quantitative) structure activity relationship ((Q)SAR) and read across (RA) analyses enable rapid and feasible hazard assessments.